Seed Meeting “NAB” (Nanomaterials as anti-biotics)
The objective of the seed meeting was to bring together specialists and researchers interested in the understanding of glycan-pathogen interactions and in the development of alternative approaches for fighting against bacterial infections to prepare for the next ITN call in 2016, other Horizon H2020 calls related to health and other nationally funded calls.
After 15 presentations around this topic we concluded the meeting with a longer discussion on the objectives and the targets we want to address in future collaborative projects. The following ideas emerged:
- The project should focus on clinical/societal needs. The research question and project direction should be defined by clinicians, which need to be identified, but several attendees have strong medical schools and therefore it is anticipated that this will not present a problem.
- Helicobacter pylori (H. pylori) was suggested as a good pathogen to focus on as it is a major clinical issue. These germs can enter your body and live in your digestive tract. It is linked to the development of ulcers and stomach cancer as well as urinary tract infections.
- Catheter-related urinary tract infections (UTI), which occur because urethral catheters inoculate organisms into the bladder and promote colonization by providing a surface for bacterial adhesion and causing mucosal irritation. Escherichia coli are most commonly responsible, but Pseudomonas, Enterococcus , Staphylococcus aureus, or Proteus mirabilis also are known to cause infection due to the formation of biofilms on catheters.
- The treatment of wound infections from polymicrobic and multidrug resistant pathogens (Pseudomonas aeruginosa, Staphylococcus aureus) with intelligent wound dressings is an additional option.
The project will aim at the :
- Prevention of biofilm formation using different inhibitor strategies.
- Sensing of the presence of pathogens in a cheap and fast manner through the development of novel strategies (e.g. polymeric fluorescent sensors responding to heat from infections).
- Treatment through the destruction of biofilms using photo-thermal and photodynamic concepts.