On the proposal of Prime Minister François Fillon, the President of the Republic has appointed:
PRIME MINISTER – M. François Fillon
| Ministre d’Etat, Minister for Ecology, Energy, Sustainable Development and Marine Affairs, responsible for Green Technology and Climate Negotiations | M. Jean-Louis Borloo |
| Ministre d’Etat, Keeper of the Seals, Minister of Justice and Freedoms | Mme Michèle Alliot-Marie |
| Minister of Foreign and European Affairs | M. Bernard Kouchner |
| Minister for the Economy, Industry and Employment | Mme Christine Lagarde |
| Minister of the Interior, Overseas France and Local Authorities | M. Brice Hortefeux |
| Minister for Labour, Solidarity and the Civil Service | M. Eric Woerth |
| Minister responsible for overseeing implementation of the economic stimulus plan | M. Patrick Devedjian |
| Minister for National Education, Government Spokesman | M. Luc Chatel |
| Minister for Higher Education and Research | Mme Valérie Pécresse |
| Minister of Defence | M. Hervé Morin |
| Minister for Health and Sport | Mme Roselyne Bachelot-Narquin |
| Minister for the Budget, Public Accounts and Administrative Reform | M. François Baroin |
| Minister for Food, Agriculture and Fisheries | M. Bruno Le Maire |
| Minister for Culture and Communication | M. Frédéric Mitterrand |
| Minister of Immigration, Integration, National Identity and Mutually-Supportive Development | M. Eric Besson |
| Minister for Rural Affairs and Town and Country Planning (Regional Development) | M. Michel Mercier |
| Minister for Youth and Active Solidarity | M. Marc-Philippe Daubresse |
| Minister responsible for Relations with Parliament, attached to the Prime Minister | M. Henri de Raincourt |
| Minister responsible for Industry, attached to the Minister for the Economy, Industry and Employment | M. Christian Estrosi |
| Minister responsible for Overseas France, attached to the Minister of the Interior, Overseas France and Local Authorities | Mme Marie-Luce Penchard |
| Minister of State responsible for Employment, attached to the Minister for the Economy, Industry and Employment | M. Laurent Wauquiez |
| Minister of State responsible for Forward Planning and Development of the Digital Economy, attached to the Prime Minister | Mme Nathalie Kosciusko-Morizet |
| Minister of State responsible for Transport, attached to the Ministre d’Etat, Minister for Ecology, Energy, Sustainable Development and Marine Affairs, responsible for Green Technology and Climate Negotiations | M. Dominique Bussereau |
| Minister of State attached to the Ministre d’Etat, Minister for Ecology, Energy, Sustainable Development and Marine Affairs, responsible for Green Technology and Climate Negotiations | Mme Valérie Létard |
| Minister of State for Justice | M. Jean-Marie Bockel |
| Minister of State responsible for Trade, Small-Scale Businesses, Small and Medium-Sized Enterprises, Tourism, Services and Consumer Affairs | M. Hervé Novelli |
| Minister of State responsible for Urban Affairs | Mme Fadela Amara |
| Minister of State for the Interior and Local Authorities | M. Alain Marleix |
| Minister of State responsible for Sport | Mme Rama Yade |
| Minister of State for Defence and Veterans | M. Hubert Falco |
| Minister of State responsible for Foreign Trade | Mme Anne-Marie Idrac |
| Minister of State responsible for the Family and Solidarity | Mme Nadine Morano |
| Minister of State responsible for Ecology | Mme Chantal Jouanno |
| Minister of State responsible for European Affairs | M. Pierre Lellouche |
| Minister of State responsible for the Elderly | Mme Nora Berra |
| Minister of State responsible for Housing and Town Planning | M. Benoît Apparu |
| Minister of State responsible for the Civil Service | M. Georges Tron |