On the proposal of Prime Minister François Fillon, the President of the Republic has appointed:
| Ministre d’Etat, Minister for Ecology, Energy, Sustainable Development and Marine Affairs, responsible for Green Technology and Climate Negotiations | M. Jean-Louis Borloo |
| Ministre d’Etat, Keeper of the Seals, Minister of Justice and Freedoms | Mme Michèle Alliot-Marie |
| Minister of the Interior, Overseas France and Local Authorities | M. Brice Hortefeux |
| Minister for Labour, Labour Relations, the Family and Solidarity | M. Xavier Darcos |
| Minister for the Budget, Public Accounts, the Civil Service and Administrative Reform | M. Eric Woerth |
| Minister for National Education, Government Spokesman | M. Luc Chatel |
| Minister for Food, Agriculture and Fisheries | M. Bruno Le Maire |
| Minister for Culture and Communication | M. Frédéric Mitterrand |
| Minister for Rural Affairs and Town and Country Planning (Regional Development) | M. Michel Mercier |
| Minister responsible for Relations with Parliament, attached to the Prime Minister | M. Henri de Raincourt |
| Minister responsible for Industry, attached to the Minister for the Economy, Industry and Employment | M. Christian Estrosi |
| Minister of State attached to the Ministre d’Etat, Minister for Ecology, Energy, Sustainable Development and Marine Affairs, responsible for Green Technology and Climate Negotiations | Mme Valérie Létard |
| Minister of State attached to the Ministre d’Etat, Keeper of the Seals, Minister of Justice and Freedoms | M. Jean-Marie Bockel |
| Minister of State responsible for Trade, Small-Scale Businesses, Small and Medium-Sized Enterprises, Tourism, Services and Consumer Affairs, attached to the Minister for the Economy, Industry and Employment | M. Hervé Novelli |
| Minister of State responsible for Sport, attached to the Minister for Health and Sport | Mme Rama Yade |
| Minister of State for Defence and Veterans, attached to the Minister of Defence | M. Hubert Falco |
| Minister of State responsible for the Family and Solidarity, attached to the Minister for Labour, Labour Relations, the Family and Solidarity | Mme Nadine Morano |
| Minister of State responsible for European Affairs, attached to the Minister of Foreign and European Affairs | M. Pierre Lellouche |
| Minister of State responsible for the Elderly, attached to the Minister for Labour, Labour Relations, the Family and Solidarity | Mme Nora Berra |
| Minister of State responsible for Housing and Town Planning, attached to the Ministre d’Etat, Minister for Ecology, Energy, Sustainable Development and Marine Affairs, responsible for Green Technology and Climate Negotiations | M. Benoît Apparu |
| Minister of State responsible for Overseas France, attached to the Minister of the Interior, Overseas France and Local Authorities | Mme Marie-Luce Penchard |
| Minister of State responsible for the Development of the Capital City Region, attached to the Prime Minister | M. Christian Blanc |
The following are confirmed in office:
| Minister of Foreign and European Affairs | M. Bernard Kouchner |
| Minister for the Economy, Industry and Employment | Mme Christine Lagarde |
| Minister responsible for overseeing implementation of the economic stimulus plan | M. Patrick Devedjian |
| Minister for Higher Education and Research | Mme Valérie Pécresse |
| Minister of Defence | M. Hervé Morin |
| Minister for Health and Sport | Mme Roselyne Bachelot-Narquin |
| Minister of Immigration, Integration, National Identity and Mutually-Supportive Development | M. Eric Besson |
| Minister of State responsible for Employment, attached to the Minister for the Economy, Industry and Employment | M. Laurent Wauquiez |
| Minister of State responsible for Forward Planning and Development of the Digital Economy, attached to the Prime Minister | Mme Nathalie Kosciusko-Morizet |
| Minister of State responsible for Transport, attached to the Ministre d’Etat, Minister for Ecology, Energy, Sustainable Development and Marine Affairs, responsible for Green Technology and Climate Negotiations | M. Dominique Bussereau |
| Minister of State responsible for Urban Affairs, attached to the Minister for Labour, Labour Relations, the Family and Solidarity | Mme Fadela Amara |
| Minister of State responsible for the Interior and Local Authorities, attached to the Minister of the Interior, Overseas France and Local Authorities | M. Alain Marleix |
| Minister of State responsible for Foreign Trade, attached to the Minister for the Economy, Industry and Employment | Mme Anne-Marie Idrac |
| Minister of State responsible for Cooperation and Francophony, attached to the Minister of Foreign and European Affairs | M. Alain Joyandet |
| Minister of State responsible for Ecology, attached to the Ministre d’Etat, Minister for Ecology, Energy, Sustainable Development and Marine Affairs, responsible for Green Technology and Climate Negotiations | Mme Chantal Jouanno |
| High Commissioner for Active Solidarity against Poverty, High Commissioner for Youth | M. Martin Hirsch |